Bcl-2 (stapled peptide) refers the stapled peptide target Bcl-2.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB17717 | BIM SAHBA | 1403993-87-2 | BIM SAHBA is a hydrocarbon-stapled peptide modeled after the BIM BH3 helix broadly. It targeted BCL-2 family proteins (with Kd values of 3.2, 10.7, 2.7 and 1.4nM for affinity to Bcl-xL, Mcl-1, Bcl-w and Bfl-1, respectively), blocked inhibitory antiapoptotic interactions, directly triggered proapoptotic activity, and induced dose-responsive and BH3 sequence–specific cell death of hematologic cancer cells. |