PPAR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00922 | Wy-14643 | 50892-23-4 | Wy-14643 is an agonist of PPARα with EC50 of 0.63 μM that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| FB00725 | Troglitazone | 97322-87-7 | Troglitazone is a PPARγ agonist with EC50 of 780 nM in murine and 555 nM in human. It has no activity at PPARα or PPARδ and can act as an anti-diabetic agent. |
| FB09847 | T0070907 | 313516-66-4 | T0070907 is an antagonist of PPARγ with IC50 of 1 nM. |
| FB00776 | Suksdorfin | 53023-17-9 | Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPARγ activation. |
| FB12696 | SR 1664 | 1338259-05-4 | SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. |
| FB12710 | SR 202 | 76541-72-5 | SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. |
| FB12652 | S26948 | 353280-43-0 | Selective PPARγ agonist; antidiabetic agent |
| FB11339 | Seladelpar | 851528-79-5 | Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor δ (PPARδ) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis. |
| FB00088 | Saroglitazar | 495399-09-2 | Saroglitazar is a peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3 nM in HepG2 cells, respectively. |
| FB02057 | Rosiglitazone Maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPARγ) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| FB09660 | Rosiglitazone | 122320-73-4 | Rosiglitazone is a selective agonist of PPARγ with EC50 of 60 nM, and has no effect on PPARα and PPARβ. It is an insulin sensitizing and potent antihyperglycemic agent. |
| FB12074 | Pparδ Agonist | 942594-93-6 | PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10. |
| FB12075 | Pparδ Agonist 1 | 1902161-12-9 | Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases. |
| FB08721 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| FB10253 | Pemafibrate | 848259-27-8 | Pemafibrateis a selective PPARα modulator (SPPARMα) that has antihyperlipidaemic activity. |
| FB10254 | Pemafibrate Racemate | 848258-31-1 | Pemafibrate racemate is a selective PPARα modulator (SPPARMα). |
| FB16596 | Oroxin A | 57396-78-8 | Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence. |
| FB08560 | Oleoylethanolamide | 111-58-0 | Oleoylethanolamide is a lipid mediator and analog of anandamide that is involved in peripheral regulation of feeding. It is also a selective GPR55 agonist (EC50 values are 0.44, > 30 and > 30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM). |
| FB09154 | MK-886 | 118414-82-7 | MK886 is an inhibitor of 5-lipoxygenase activating protein (FLAP), PPARα, and the biosynthesis of leukotriene (LT). |
| FB01464 | MHY553 | 6265-56-1 | MHY553, a PPARα agonist, alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. |
| FB16781 | MA-0204 | 2095128-17-7 | MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. It is potential for Duchene Muscular Dystrophy treatment. |
| FB11328 | IVA-337 | 927961-18-0 | IVA-337 is a agonist of peroxisome proliferator-activated receptors (PPAR) which is widely used in the study of lung fibrosis and pulmonary hypertension. |
| FB17778 | Gypenoside XLIX | 94987-08-3 | Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells. |
| FB17199 | GW7647 | 265129-71-3 | GW7647 is a potent human PPARα agonist with EC50 value of 6nM. |
| FB07428 | GW501516 | 317318-70-0 | GW501516 is a selective agonist of PPARβ/δ with EC50 of 1 nM and is a potential candidate for the treatment of metabolic diseases and cardiovascular diseases. |
| FB02604 | GW0742 | 317318-84-6 | GW0742 is an agonist of PPARδ with EC50 of 1.1 nM. It can protect right heart from hypertrophy and enhance lipid metabolism in heart. It also works as an antagonist of vitamin D receptor. |
| FB12024 | GW 6471 | 880635-03-0 | GW 6471 is a potent PPARα antagonist. |
| FB12324 | GW 1929 HCl | 1217466-21-1 | GW 1929 HCl is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist with pEC50 of 8.05 for human PPARγ. |
| FB08326 | GSK3787 | 188591-46-0 | GSK3787 selectively and irreversibly antagonizes PPARδ with pIC50 of 6.6 with no significant effect on hPPARα or hPPARγ. |
| FB08114 | GSK0660 | 1014691-61-2 | GSK0660 is a selective antagonist of PPARβ/δ and exhibits inverse agonist effects when used alone. |
| FB01066 | Gemfibrozil | 25812-30-0 | Gemfibrozil is an agonist of PPARα. It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides. |
| FB12005 | Fonadelpar | 515138-06-4 | Fonadelpar is a PPARδ agonist, used in the research of neuroparalytic keratopathy. |
| FB05719 | Ficusin A | 173429-83-9 | Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn. |
| FB00840 | Fenofibric Acid | 42017-89-0 | Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2. |
| FB02186 | Fenofibrate | 49562-28-9 | Fenofibrate is an agonist of PPARα (EC50 = 30 μM) and an inhibitor of CYP2C19 (IC50 = 0.2 μM) and CYP2B6 (IC50 = 0.7 μM). Fenofibrate is a fibric acid derivative and used to treat hypercholesterolemia and hypertriglyceridemia. |
| FB04236 | Eupatilin | 22368-21-4 | Eupatilin is an activiator of PPARα. It is a lipohilic flavonoid extracted from artemisia species with antioxidant, anti-tumor, and anti-inflammatory activities. |
| FB04801 | Elafibranor | 923978-27-2 | Elafibranor is an agonist of PPARα and PPARδ with EC50 values of 45 nM and 175 nM, respectively. Elafibranor also attenuates nonalcoholic steatohepatitis without fibrosis worsening. |
| FB12558 | Edaglitazone | 213411-83-7 | Edaglitazone is a potent and selective PPARγ agonist with EC50 of 35.61 nM. |
| FB02798 | DG172 2HCl | 1361504-77-9 | DG172 2HCl is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties. |
| FB12279 | CP 775146 | 702680-17-9 | CP 775146 is a selective, high affinity PPARα agonist with Ki of 24.5 nM. |
| FB10540 | Clofibric Acid | 882-09-7 | Clofibric acid is an agonist of PPARα and can act as a hypolipidemic agent. |
| FB16220 | Cinnamyl alcohol | 104-54-1 | Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. |
| FB12513 | Ciglitazone | 74772-77-3 | Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro. |
| FB05122 | CDDO-Im | 443104-02-7 | CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPARγ agonist. |
| FB01910 | BMS-687453 | 1000998-59-3 | BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. |
| FB04057 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-γ. |
| FB12590 | BADGE | 1675-54-3 | BADGE is a PPARγ antagonist. |
| FB04456 | Arjunolic Acid | 465-00-9 | Arjunolic acid, a natural peroxisome proliferator-activated receptor alpha agonist isolated and purified from the fruits of Terminalia chebula Retz., can protect against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS, TNF-α, and p38-MAPK testicular expressions. |
| FB07046 | AMG-131 | 315224-26-1 | AMG-131 is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs. |
| FB04131 | 4-(4-Hydroxyphenyl)-2-Butanone | 5471-51-2 | 4-(4-Hydroxyphenyl)-2-butanone is the primary aroma compound of red raspberries and shows PPAR-α agonistic activity. |