P2Y Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB17222 | YM-254890 | 568580-02-9 | YM-254890 works as both a selective inhibitor of the Gq protein subfamily and a novel platelet aggregation inhibitor with IC50 value below 0.6μM by blocking the P2Y1 receptor-signal transduction pathway. It isolated from the culture broth of strain QS3666. |
| FB17854 | Uridine 5′-diphosphoglucose disodium salt | 28053-08-9 | Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR. |
| FB12846 | UDP disodium salt | 27821-45-0 | UDP disodium salt is an endogenous agonist of P2Y receptor which preferentially activates P2Y6. It exhibis antagonistic effect on the P2Y14 receptor. |
| FB00179 | Ticlopidine | 55142-85-3 | Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. |
| FB01494 | Ticlopidine HCl | 53885-35-1 | Ticlopidine HCl is an adenosine diphosphate (ADP) receptor inhibitor that against platelet aggregation with IC50 of ~2 μM. |
| FB07024 | Ticagrelor | 274693-27-5 | Ticagrelor is a reversibly and oral active P2Y12 receptor antagonist with Ki of 2 nM, also inhibits CYP2C9 and midazolam 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively. |
| FB09640 | Suramin Sodium | 129-46-4 | Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM). |
| FB03251 | Suramin | 145-63-1 | Suramin is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors(10-100 μM). |
| FB10997 | PSB-0739 Sodium | 1052087-90-7 | PSB-0739 is an extremely potent and selective competitive P2Y12 receptor antagonist (pA2 of 9.8). |
| FB04938 | Prasugrel Maleic Acid | 389574-20-3 | Prasugrel maleic acid is a platelet inhibitor with IC50 value of 1.8 μM. |
| FB07109 | Prasugrel | 150322-43-3 | Prasugrel is a platelet inhibitor with IC50 value of 1.8 μM. |
| FB02119 | Prasugren HCl | 389574-19-0 | Prasugrel HCl is a platelet inhibitor with IC50 value of 1.8 μM. |
| FB03123 | N6-(4-Hydroxybenzyl)-adenosine | 110505-75-4 | N6-(4-Hydroxybenzyl)adenosine is an inhibitor of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). |
| FB06531 | MRS 2578 | 711019-86-2 | MRS2578 is a potent and selective P2Y6 nucleotide receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
| FB10996 | MRS2395 | 491611-55-3 | MRS2395 is an antagonist for the P2Y12 purinoceptor, which causes platelet aggregation in rats via ADP induction. |
| FB15310 | Diquafosol Tetrasodium | 211427-08-6 | Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease. |
| FB02431 | Clopidogrel Thiolactone | 1147350-75-1 | Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent. |
| FB10468 | Clopidogrel Bisulfate | 135046-48-9 | Clopidogrel is an inhibitor of platelet aggregation that is used to decrease the risk of myocardial infarction and stroke in patients known to have atherosclerosis. Clopidogrel has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury. |
| FB07658 | Clopidogrel | 113665-84-2 | Clopidogrel is a P2Y12 receptor blocker (IC50 = 100 nM). |
| FB10730 | Clopidogrel Hydrogen Sulfate | 120202-66-6 | Clopidogrel Hydrogen Sulfate is the functional enantiomer of clopidogrel and a potent P2Y12 receptor antagonist. |
| FB11358 | Cangrelor tetrasodium | 163706-36-3 | Cangrelor is a potent and competitive P2Y12 receptor inhibitor that inhibits of ADP-induced platelet aggregation. |
| FB11351 | BPTU | 870544-59-5 | BPTU allosteric antagonist of P2Y1 wtih IC50 of 0.06-0.3 μM with antithrombotic effect and reduces platelet aggregation. |
| FB06945 | AZD1283 | 919351-41-0 | AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI > 10 and with binding IC50 of 11 nM. |
| FB10998 | AR-C 66096 Tetrasodium | 145782-74-7 | AR-C 66096 tetrasodium is a potent and selective P2Y12 receptor antagonist which blocks ADP-induced inhibition of adenylyl cyclase in vitro (pKB =7.6) and inhibits ADP-induced aggregation of washed human platelets (pIC50 = 8.16). |