Integrin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB03054 | Zaurategrast | 455264-31-0 | Zaurategrast is an oral α4-integrin inhibitor. |
| FB05346 | TR-14035 | 232271-19-1 | TR-14035 is a dual antagonist of both integrin α4β7 and integrin α4β1 with IC50 values of 7 nM and 87 nM, respectively, used as an anti-inflammatory agent. |
| FB00233 | Tirofiban | 144494-65-5 | Tirofiban is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIb/IIIa receptor used as an antiplatelet drug. |
| FB10651 | Tirofiban HCl H2O | 150915-40-5 | Tirofiban HCl H2O is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIb/IIIa receptor used as an antiplatelet drug. |
| FB11813 | MK-0429 | 227963-15-7 | MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively. |
| FB09911 | Lifitegrast | 1025967-78-5 | Lifitegrast is a novel small molecule integrin antagonist which can inhibit an integrin, lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular adhesion molecule 1 (ICAM-1). |
| FB10385 | Leukadherin-1 | 344897-95-6 | Leukadherin-1 is allosteric activator of CD11b/CD18 with EC50 value of 4 μM for increasing CD11b/CD18-dependent cell adhesion to fibrinogen. |
| FB06206 | Integrin Antagonist 27 | 593274-97-6 | Integrin antagonist 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as an anticancer agent. |
| FB03948 | Integrin Antagonist 1 HCl | 1629249-40-6 | Integrin antagonist 1 HCl is a small molecule integrin αvβ6 antagonist. |
| FB09450 | SB-273005 | 205678-31-5 | In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. |
| FB09959 | GLPG0187 | 1644644-90-5 | GLPG0187 is a small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity and inhibits αvβ1-integrin with an IC50 of 1.3 nM. |
| FB19598 | GLPG 0187 | 1320346-97-1 | GLPG 0187 is a potent αv integrin inhibitor with IC50 values of 1.2-3.7 nM. It inhibits osteoclastic bone resorption and angiogenesis in vitro and in vivo. Also it suppresses epithelial-mesenchymal transition (EMT) and migration of PC-3M-Pro4/luc cells, without inhibiting cell growth. |
| FB01041 | Firategrast | 402567-16-2 | Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). |
| FB01351 | Eptifibatide | 188627-80-7 | Eptifibatide is a specific inhibitor of fibrinogen working by binding to the platelet membrane integrin αIIbβ3 receptor and preventing platelet aggregation. |
| FB12121 | Eptifibatide Acetate | 881997-86-0 | Eptifibatide Acetate is a cyclic heptapeptide that shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes. |
| FB10258 | E-7820 | 289483-69-8 | E7820 is an angiogenesis inhibitor by suppressing integrin a2, a cell adhesion molecule expressed on endothelial cells. |
| FB10202 | Cyclo(RGDyK) | 250612-42-1 | Cyclo(RGDyK) is a highly potent and selective inhibitor for the αvβ3 integrin with a IC50 of 0.94 nM. |
| FB10201 | Cyclo(-RGDfK) Trifluoroacetate | 500577-51-5 | Cyclo(-RGDfK) Trifluoroacetate is a highly potent and selective inhibitor for the αvβ3 integrin with a IC50 of 0.94 nM. |
| FB03930 | Cyclo(-RGDfK) | 161552-03-0 | Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin. |
| FB02221 | CWHM-12 | 1564286-55-0 | CWHM-12 is a small molecule inhibitor of αV integrins with IC50s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8, and is less potency on αvβ5 (IC50=61 nM) and on inhibition on αIIbβ3/α2β1/α10β1. |
| FB10169 | Cilengitide Trifluoroacetate | 199807-35-7 | Cilengitide Trifluoroacetate is a cyclic RGD pentapeptide antagonist of integrins αvβ3, αvβ5 and α5β1. |
| FB09427 | Cilengitide | 188968-51-6 | Cilengitide is a cyclic RGD pentapeptide antagonist of integrins αvβ3, αvβ5 and α5β1. |
| FB06925 | ATN-161 Trifluoroacetate | 904763-27-5 | ATN-161 trifluoroacetate is a five-amino-acid peptide derived from the synergy region of fibronectin and a beta integrin antagonist with antitumor activity. |
| FB04848 | ATN-161 | 262438-43-7 | ATN-161 is a five-amino-acid peptide derived from the synergy region of fibronectin and a beta integrin antagonist with antitumor activity. |
| FB07808 | Arg-Gly-Asp-Ser | 91037-65-9 | Arg-Gly-Asp-Ser (RGDS) is a synthetic integrin antagonist, a specific peptide motif through which extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells. |
| FB12916 | Arg-Gly-Asp TFA | 120103-89-1 | Arg-Gly-Asp TFA is the TFA salt form of Arg-Gly-Asp, which is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. |
| FB07806 | Arg-Gly-Asp | 99896-85-2 | Arg-Gly-Asp is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. |
| FB16027 | ADH-503 | 2055362-74-6 | ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. |
| FB08736 | A-205804 | 251992-66-2 | A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. |
| FB05504 | (-)-Variabilin | 370102-93-5 | (-)-Variabilin, a natural product isolated and purified from the roots of Angelica sinensis, is an inhibitor of human platelet aggregation. |