CAS:42924-53-8Nabumetone

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Synonyms: BRL-14777

Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and its active metabolite inhibits the COX.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

42924-53-8

储存条件

分子式

C15H16O2

运输

蓝冰

分子量

228.29

别名

BRL-14777

溶解度

动物实验配方

生物活性

描述Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA. Nabumetone (50 μmol - 2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR (Adriamycin) in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression^[3]. An oral dose of nabumetone (79 mg/kg) or intravenous 6MNA produced effective anti-inflammatory activity together with significant inhibition of paw exudate PGE2. An anti-inflammatory oral dose of nabumetone or intravenous 6MNA produced minimal effects on gastric 6-keto-PGF1 alpha production, with an absence of gastric damage, in contrast to indomethacin^[4]. When compared with currently available NSAIDs, nabumetone may be associated with a significantly lower incidence of gastroduodenal ulcer, and that nabumetone also appears to be safer for use in elderly patients and in those with renal or hepatic impairment^[5].