Dehydrogenase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB06258 | Vidofludimus | 717824-30-1 | Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug. |
| FB00504 | Trilostane | 13647-35-3 | Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome. |
| FB20309 | 11beta-Hydroxyprogesterone | 600-57-7 | The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. |
| FB10488 | Teriflunomide(Random Configuration) | 108605-62-5 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| FB10564 | Teriflunomide | 163451-81-8 | Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. |
| FB12707 | TC HSD 21 | 330203-01-5 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1]. |
| FB09385 | Sodium 2,2-dichloroacetate | 2156-56-1 | Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties. |
| FB11423 | RRx-001 | 925206-65-1 | RRx-001 is a potent inhibitor of glucose 6-phosphate dehydrogenase (G6PD). |
| FB15624 | Pyrazinecarboxylic acid | 98-97-5 | Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD. |
| FB08204 | Phenylglyoxal hydrate | 1075-06-5 | Phenylglyoxal Hydrate is a potent inhibitor of mitochondrial aldehyde dehydrogenase (ALDH), binding the arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties. |
| FB12769 | Oxalacetic Acid | 328-42-7 | Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH. |
| FB01491 | Mycophenolic Acid | 24280-93-1 | Mycophenolic Acid is an an immunosuppresant agent with a potent inibition of IMPDH (inosine monophosphate dehydrogenase) and potent anti-proliferative activity, it can be isolated from several Penicillium species. |
| FB03922 | Mycophenolate Mofetil | 128794-94-5 | Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. |
| FB10387 | ML390 | 2029049-79-2 | ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia. |
| FB01807 | Leflunomide | 75706-12-6 | Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 2.5 μM, it is a disease-modifying antirheumatic drug (DMARD) and inhibits de novo pyrimidine synthesis. |
| FB12040 | LDH-IN-1 | 1964515-43-2 | LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. |
| FB16061 | LDH-A Inhibitor III | 1269802-68-7 | LDH-A Inhibitor III is a potent and reversible LDH-A inhibitor. |
| FB03079 | Isovaleramide | 541-46-8 | Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii. |
| FB17210 | HQNO | 341-88-8 | HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2. |
| FB18854 | GSK2837808A | 1445879-21-9 | GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. |
| FB10398 | GNE-140 Racemate | 1802977-61-2 | GNE-140 racemate is a LDHA inhibitor. |
| FB05956 | Glycyrrhizic Acid | 1405-86-3 | Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1. |
| FB00535 | Gimeracil | 103766-25-2 | Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood and inhibits homologous recombination. |
| FB01738 | Fomepizole | 7554-65-6 | Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase which plays a key role in the metabolism of ethylene glycol and methanol. |
| FB00762 | Crocetin | 27876-94-4 | Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer. |
| FB08313 | CPI-613 | 95809-78-2 | CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer. |
| FB09179 | Carbenoxolone | 5697-56-3 | Carbenoxolone is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. |
| FB09180 | Carbenoxolone Disodium | 7421-40-1 | Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. |
| FB16584 | Brequinar | 96187-53-0 | Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. |
| FB11344 | BMS-823778 | 1140898-87-8 | BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is an antihyperglycaemic that may be a potential candidate for Type 2 diabetes treatment. |
| FB11032 | BMS-816336 | 1009583-20-3 | BMS-816336, a hydroxyl-substituted adamantyl acetamide, has been identified as a potent inhibitor against human 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1) enzyme (IC50 3.0 nM) with > 10000 fold selectivity over human 11β-hydroxysteroid dehydrogenase type 2(11β-HSD2). |
| FB10865 | BI-135585 | 1114561-85-1 | BI-135585 is a potent and selective 11β-HSD1 inhibitor for treating Type 2 diabetes. |
| FB16845 | BAY 2402234 | 2225819-06-5 | BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor. It potently inhibited proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range in vitro and exhibited strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. |
| FB07754 | AZD4017 | 1024033-43-9 | AZD4017 is a potent, selective, and orally bioavailable11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. |
| FB16829 | AZ 33 | 1370290-34-8 | AZ 33 is a Lactate Dehydrogenase A inhibitor with IC50 value of 0.5μM. |
| FB12282 | ASP 9521 | 1126084-37-4 | ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3. |
| FB12133 | Ammonium Glycyrrhizinate(x:1) | 1407-03-0 | Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. |
| FB12889 | 3-Methylpyrazole | 1453-58-3 | 3-Methylpyrazole is a nitrification inhibitor of nitrification in soil. |
| FB17972 | 2-Bromoacetamide | 683-57-8 | 2-Bromoacetamide can inactivate alcohol dehydrogenase. |
| FB12369 | (R)-GNE-140 | 2003234-63-5 | (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50s of 3 nM and 5 nM for LDHA and LDHB respectively. |
| FB18186 | DHODH-IN-11 | 1263303-95-2 | |
| FB16615 | Brequinar sodium | 96201-88-6 |