Chk
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12720 | TCS 2312 | 838823-31-7 | TCS2312 is a novel potent and selective CHK1 kinase inhibitor. |
| FB06773 | SCH-900776 S-Isomer | 891494-64-7 | SCH-900776 is the S-isomer form of SCH900776, which is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM). |
| FB09876 | SAR-020106 | 1184843-57-9 | SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC (50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G (2) arrest with an IC (50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. |
| FB01131 | PF-477736 | 952021-60-2 | PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes and shows ~100-fold selectivity for Chk1 than Chk2. |
| FB12505 | PD 407824 | 622864-54-4 | PD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 with IC50s of 47 and 97 nM respectively. |
| FB12413 | NSC 109555 Ditosylate | 66748-43-4 | NSC 109555 Ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 μM. |
| FB11214 | MU380 | 2109805-78-7 | MU380 is a potent selective inhibitor of CHK1 kinase possessing unusual N-trifluoromethylpyrazole pharmacophore resistant to metabolic N-dealkylation |
| FB01486 | Prexasertib | 1234015-52-1 | LY2606368 is a potent and selective ATP competitive inhibitor (IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. |
| FB02393 | LY2606368 2HCl | 1234015-54-3 | LY2606368 (Prexasertib) is a selective Chk1 inhibitor with IC50 value <1nM, modest to Chk2 and Rsk with IC50 values of 8nM and <10nM. |
| FB01109 | LY2603618 | 911222-45-2 | LY2603618 is a highly selective Chk1 inhibitor with potential anti-tumor activity. In a cell-free assay, it shows an IC50 of 7 nM, approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. |
| FB11599 | SB 218078 | 135897-06-2 | Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. |
| FB12873 | GDC-0575 | 1196541-47-5 | GDC-0575 is a potent and selective CHK1 inhibitor. |
| FB11752 | CHK1 inhibitor | 2097938-64-0 | GDC-0575 is a potent and selective CHK1 inhibitor. |
| FB12873 | GDC-0575 | 1196541-47-5 | GDC-0575 is a potent and selective CHK1 inhibitor. |
| FB11071 | GDC-0425 | 1200129-48-1 | GDC-0425 is an oral, selective Chk1 inhibitor. GDC-0425 enhances gemcitabine (gem) efficacy in tumor xenograft models, and shows greater chemopotentiation in cancer cell lines lacking p53 activity. |
| FB08542 | CHIR-124 | 405168-58-3 | CHIR-124 is a potent Chk1 inhibitor with IC50 of 0.3 nM with 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2. |
| FB09972 | CCT245737 | 1489389-18-5 | CCT245737 is a potent, ATP-competitive CHK1 inhibitor with an IC50 of 30-220 nM. |
| FB10053 | CCT244747 | 1404095-34-6 | CCT244747 is potent, highly selective, orally active, ATP competitive CHK1 inhibitor with IC50 of 29-170nM. |
| FB02690 | CCT241533 | 1262849-73-9 | CCT241533 is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 μM. |
| FB03215 | CCT241533 HCl | 1431697-96-9 | CCT241533 HCl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM and shows minimal cross-reactivity against a panel of kinases at 1 μM. |
| FB03536 | BML-277 | 516480-79-8 | BML-277 is a selective Chk2 (checkpoint kinase 2) inhibitor with IC50 of 15 nM. |
| FB08122 | AZD7762 | 860352-01-8 | AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM, being equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. |
| FB12344 | AZD 7762 HCl | 1246094-78-9 | AZD 7762 HCl is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2, both with IC50 of 5 nM. |
| FB10852 | N/A | 1196541-47-5 | |
| FB10852 | N/A | 1196541-47-5 |