Hedgehog
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB05364 | Vismodegib | 879085-55-9 | Vismodegib is an inhibitor of hedgehog pathway with IC50 of 3 nM and also inhibits P-gp (IC50 = 3.0 μM). |
FB06214 | Veratramine | 60-70-8 | Veratramine is a natually occuring alkaloid isolated from the rhizomes of Veratrum and can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells for it is an analog of cyclopamine. |
FB10170 | SANT-1 | 304909-07-7 | SANT-1 can directly bind to Smoothened (Smo) receptor with Kd of 1.2 nM. It also exhibits inhibition of Smo agonist effects (IC50 = 20 nM). |
FB01951 | RU-SKI 43 | 1043797-53-0 | RU-SKI 43 is a small molecule inhibitor of Hhat (Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. |
FB10152 | RU-SKI 43 HCl | 1782573-67-4 | RU-SKI 43 HCl is a small molecule inhibitor of Hhat (Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. |
FB03007 | Mebendazole | 31431-39-7 | Mebendazole is an inhibitor of hedgehog and a broad spectrum antihelmintic for the treatment of nematode infestations. |
FB02464 | JK184 | 315703-52-7 | JK184 is a hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells. |
FB11145 | Hedgehog Inhibitor C15h | 1616368-12-7 | Hedgehog inhibitor C15h displays a potent hedgehog-inhibitory activity with an IC50 of 0.050 nM. |
FB10150 | Ciliobrevin A | 302803-72-1 | Ciliobrevin A inhibits hedgehog (Hh) signaling pathway with IC50 less than 10 μM. |
FB12589 | AY 9944 2HCl | 366-93-8 | AY 9944 2HCl is an inhibitor of hedgehog (Hh) signaling. |
FB16383 | 20(S)-Hydroxycholesterol | 516-72-3 | 20(S)-Hydroxycholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein. It activates Hedgehog (Hh) signaling with EC50 value of ~ 3μM for induction of Hh reporter gene transcription in NIH 3T3 cells. |