Cathepsin
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB02726 | VBY-825 | 1310340-58-9 | VBY-825 is a reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V. |
| FB16853 | Relacatib | 362505-84-8 | Relacatib is developed as a cathepsin K inhibitor but has activity against cathepsin L that may provide potential to block SARS-Cov-2 entry into host cells. |
| FB16551 | Petesicatib | 1252637-35-6 | Petesicatib is a cathepsin S inhibitor, used in immune diseases research. |
| FB11252 | ONO-5334 | 868273-90-9 | ONO-5334 is a potent and orally available inhibitor of cathepsin K (Ki values of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat respectively). |
| FB07703 | Odanacatib | 603139-19-1 | Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. |
| FB12056 | MIV-247 | 1352817-76-5 | MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively. |
| FB09158 | MG-101 | 110044-82-1 | MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). |
| FB11129 | MDL28170 | 88191-84-8 | MDL28170 is a potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. MDL28170 rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. |
| FB02806 | LY3000328 | 1373215-15-6 | LY 3000328 is a highly selective and potent Cathepsin S inhibitor with IC50 of 7.7±5.85 nM and 1.67±1.17 nM for hCat S and mCat S respectively, can be used in treatment for abdominal aortic aneurysm. |
| FB01943 | Leupeptin Hemisulfate | 103476-89-7 | Leupeptin Hemisulfate is a reversible serine/cysteine protease inhibitor, inhibits cathepsins B, H, L, and S, calpain, and trypsin. |
| FB17594 | L-Homocysteine | 6027-13-0 | L-Homocysteine, a homocysteine metabolite, is a homocysteine that has L configuration. L-Homocysteine induces upregulation of cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia . |
| FB12571 | L 006235 | 294623-49-7 | L 006235 is a potent, reversible cathepsin K inhibitor with IC50 of 0.25 nM. |
| FB01387 | Furan-2-Carboxylic Acid | 88-14-2 | Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis. |
| FB12665 | SID 26681509 | 958772-66-2 | Cathepsin L inhibitor |
| FB10161 | Cathepsin Inhibitor 1 | 225120-65-0 | Cathepsin inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
| FB08806 | Cathepsin G inhibitor I | 429676-93-7 | Cathepsin G inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (IC50 = 53 nM and Ki = 63 nM). |
| FB12468 | Calpain Inhibitor II | 145757-50-2 | Calpain Inhibitor II is an inhibitor of calpain. |
| FB03829 | CA-074 Methyl Ester | 147859-80-1 | CA-074 Methyl Ester is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. |
| FB12292 | CA 074 | 134448-10-5 | CA 074 is an inhibitor of cathepsin B with Ki of 2 - 5 nM. |
| FB01529 | Balicatib | 354813-19-7 | Balicatib is a potent and selective inhibitor of cathepsin K ,with 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. |
| FB10932 | AZD7986 | 1802148-05-5 | AZD7986 is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. |
| FB08463 | 5,5-Dimethyl-2,4-oxazolidinedione | 695-53-4 | 5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, it's an anticonvulsant. |
| FB16599 | 2-cyano-Pyrimidine | 14080-23-0 | 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos. |
| FB04467 | 1-Hydroxyrutaecarpine | 53600-24-1 | 1-Hydroxyrutaecarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa (Juss.) Benth., exhibits cytotoxicities (ED50 values < 4 mg/mL) against P-388 or HT-29 cell lines in vitro and antiplatelet activity induced by AA and shows an IC50 value of ca.1-2 mg/mL. |