TAM Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB02666 | UNC2881 | 1493764-08-1 | UNC2881 is a Mer kinase inhibitor and can inhibit the phosphorylation of Mer with IC50 of 4.3 nM. |
| FB01086 | UNC2250 | 1493694-70-4 | UNC2250 is an inhibitor of Mer with IC50 of 1.7 nM. |
| FB02759 | TP-0903 | 1341200-45-0 | TP-0903 is a selective Axl kinase inhibitor with IC50 of 27 nM. |
| FB00445 | SGI-7079 | 1239875-86-5 | SGI-7079, a selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance. |
| FB12127 | RXDX-106 | 1437321-24-8 | RXDX-106 inhibits TAM and c-MET phosphorylation in vitro. This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability. It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells. |
| FB11866 | R916562 | 1037798-41-6 | R916562 is a potential and selective Axl/VEGF-R2 dual inhibitor with IC50s of 136 and 24 nM, respectively. |
| FB07676 | R428 R-Enantiomer | 1037624-76-2 | R428 R-enantiomer is an R isomer of R428, a potent and selective small-molecule inhibitor (IC50=14 nM), blocks the activities of Axl. |
| FB01110 | R428 | 1037624-75-1 | R428 is a potent and selective small-molecule inhibitor (IC50=14 nM), and blocks the activities of Axl. |
| FB16839 | ONO-7475 | 1646839-59-9 | ONO-7475 is a potent and selective inhibitor of active novel Axl/Mer tyrosine kinase with IC50 values of 0.7nM and 1nM, respectively. It potently arrested growth and induced apoptosis in acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3. |
| FB10192 | NPS-1034 | 1221713-92-3 | NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively. |
| FB01448 | LDC1267 | 1361030-48-9 | LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of < 5 nM, 8 nM, 29 nM, respectively. |