Potassium Channel
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB08934 | VU 0240551 | 893990-34-6 | VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). |
| FB00352 | Vernakalant | 794466-70-9 | Vernakalant is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents used in treatment of antiarrhythmic. |
| FB00351 | Vernakalant HCl | 748810-28-8 | Vernakalant HCl prolongs repolarization by blocking atrial potassium channels, it's a class III antiarrhythmics. |
| FB06820 | UK-78282 HCl | 136647-02-4 | UK-78282 is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively) which suppresses T lymphocyte mitogenesis and leads to membrane depolarization and also blocks KV1.4 expressed in heart and brain. |
| FB02560 | TRAM-34 | 289905-88-0 | TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). |
| FB00278 | Tolbutamide | 64-77-7 | Tolbutamide is a potassium channel blocker, sulfonylurea oral hypoglycemic drug. |
| FB09734 | Terfenadine | 50679-08-8 | Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM. |
| FB03731 | TAK 438 Fumarate | 881681-01-2 | TAK-438, a potassium proton pump inhibitor, can reversibly inhibit H+/K+ ATPase with IC50 of 17 nM and does not affect Na+/K+ ATPase. It also controls gastric acid secretion. |
| FB02189 | Sophocarpine | 6483-15-4 | Sophocarpine is a naturally-occuring HERG K+ channel blocker with IC50 ranging in 100-300 μM found from plant Sophora flavescens. |
| FB03813 | Senicapoc | 289656-45-7 | Senicapoc is a potent and selective Gardos channel blocker and blocks Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively. |
| FB08301 | RPR-260243 | 668463-35-2 | RPR-260243 is an activator of HERG which modifies HERG currents inhibited by dofetilide (IC50 = 58 nM) and shows little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. |
| FB10500 | Retigabine | 150812-12-7 | Retigabine is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity. |
| FB10529 | Retigabine 2HCl | 150812-13-8 | Retigabine 2HCl is an anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels. |
| FB07707 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| FB02585 | PAP-1 | 870653-45-5 | PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity. |
| FB04916 | NS-6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
| FB01781 | NS-309 | 18711-16-5 | NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels). It increases Ca2+ sensitivity and displays no activity at BK channels. |
| FB06822 | NS-1643 | 448895-37-2 | NS-1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM. |
| FB02226 | NS-1619 | 153587-01-0 | NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. |
| FB07591 | Nigericin Sodium | 28643-80-3 | Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore. |
| FB07629 | Nifekalant HCl | 130656-51-8 | Nifekalant HCl is an antiarrhythmic shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage- and frequency-dependent manner. |
| FB07820 | Nicorandil | 65141-46-0 | Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). |
| FB08277 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| FB03158 | ML277 | 1401242-74-7 | ML277 is a potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. |
| FB09767 | ML133 HCl | 1222781-70-5 | ML133 HCl selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. |
| FB01625 | Mitiglinide Calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
| FB05531 | Minoxidil Sulfate | 83701-22-8 | Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. It has been shown to relax norepinephrine contraction, and is reported to be a vasodilator. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability. |
| FB05948 | Minoxidil | 38304-91-5 | Minoxidil is an antihypertensive vasodilator medication. |
| FB02875 | Indapamide | 26807-65-8 | Indapamide is a thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure. |
| FB02624 | Hydralazine HCl | 304-20-1 | Hydralazine HCl is a direct-acting vasodilator that is used as an antihypertensive agent. |
| FB02132 | Gliquidone | 33342-05-1 | Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| FB02131 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| FB00577 | Glimepiride | 93479-97-1 | Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 3.0 nM in pancreatic β-cells with fewer cardiac actions. It is used in the treatment of type 2 diabetes mellitus. |
| FB06716 | Gliclazide | 21187-98-4 | Gliclazide is a blocker of pancreatic β-cell ATP-sensitive potassium channels with IC50 of 184 nM in murine. It belongs to the sulfonylurea class of insulin secretagoguesIt. Gliclazide is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| FB03349 | Glibenclamide | 10238-21-8 | Glibenclamide is a sulfonylurea compound that modulates insulin production. |
| FB09175 | Flupirtine | 56995-20-1 | Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. |
| FB01857 | E-4031 2HCl | 113559-13-0 | E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel. |
| FB10466 | Doxapram | 309-29-5 | Doxapram inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| FB08897 | Doxapram HCl H2O | 7081-53-0 | Doxapram HCl, a respiratory stimulant, exhibits inhibition of TASK-1 (EC50 = 410 nM), TASK-3 (EC50 = 37 nM) and TASK-1/TASK-3 heterodimeric (EC50 = 9 nM) channel function. It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center. |
| FB07879 | Dofetilide | 115256-11-6 | Dofetilide is a potassium channel blocker that acts as a class III antiarrhythmic drug. It is used for the treatment of atrial fibrillation and flutter. |
| FB00525 | Diazoxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| FB00321 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM. |
| FB03968 | BMS-191095 | 166095-21-2 | BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. |
| FB07916 | Azimilide | 149908-53-2 | Azimilide is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. |
| FB03269 | Azimilide 2HCl | 149888-94-8 | Azimilide 2HCl, a class III antiarrhythmic compound, blocks the Kv7.1 and Kv11.1 patassium channels. It also inhibits Na+/Ca2+ exchanger in vitro. |
| FB07671 | Amiodarone | 1951-25-3 | Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
| FB05343 | Amiodarone HCl | 19774-82-4 | Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. |
| FB03883 | Ajmaline | 4360-12-7 | Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent. |
| FB07228 | 4-Aminopyridine | 504-24-5 | 4-Aminopyridine (4-AP) is a non-selective blocker of K+ channel with IC50 of 170 µM and 230 µM respectively for Kv1.1 and Kv1.2. 4-Aminopyridine has benefits against multiple sclerosis. |
| FB07697 | 20-HETE | 79551-86-3 | 20-HETE is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. |