CAS:364-98-73-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide

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Diazoxide 3-甲基-7-氯-1,2,4-苯并噻二嗪1,1-二氧化物 Cat No. FB00525Cas No. 364-98-7

Synonyms: SCH 6783;SRG 95213

Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3352 mL
- 21.6760 mL
- 43.3520 mL
- 5 mM
- 0.8670 mL
- 4.3352 mL
- 8.6704 mL
- 10 mM
- 0.4335 mL
- 2.1676 mL
- 4.3352 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

364-98-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C8H7ClN2O2S

运输

蓝冰

分子量

230.67

别名

SCH 6783;SRG 95213

溶解度

DMSO	165.0 mg/mL (715.3 mM) warming
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment. Diazoxide has powerful protective properties against cardiac ischemia. Diazoxide may have several potential effectors that may potentially contribute to cardioprotection, including KATP channels in the pancreas, smooth muscle, endothelium, neurons and the mitochondrial inner membrane. Diazoxide may also affect other ion channels and ATPases and may directly regulate mitochondrial energetics^[3]. Diazoxide is a neuroprotective agent against oxidative stress-induced damage and cellular dysfunction. Diazoxide effectively protects NSC-34 motoneurons from glutamatergic, oxidative and inflammatory damage. Moreover, diazoxide decreased neuronal death in organotypic hippocampal slice cultures after exicitotoxicity and preserved myelin sheath in organotypic cerebellar cultures exposed to pro-inflammatory demyelinating damage^[4]. Diazoxide attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels^[5].