CAS:289656-45-7Senicapoc

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Senicapoc 塞尼卡泊 Cat No. FB03813Cas No. 289656-45-7

Synonyms: ICA-17043

Senicapoc is a potent and selective Gardos channel blocker and blocks Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0928 mL
- 15.4638 mL
- 30.9276 mL
- 5 mM
- 0.6186 mL
- 3.0928 mL
- 6.1855 mL
- 10 mM
- 0.3093 mL
- 1.5464 mL
- 3.0928 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

289656-45-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C20H15F2NO

运输

蓝冰

分子量

323.34

别名

ICA-17043

溶解度

DMSO	50.0 mg/mL (154.6 mM) warming

动物实验配方

靶点数据

生物活性

描述Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM. Senicapoc is a potent inhibitor of the Gardos channel and ameliorates RBC (red blood cells) dehydration in the SAD mouse. Senicapoc is shown to block the Gardos channel of mouse (C57 Black) RBCs with an IC50 of 50 ± 6 nM. Senicapoc blocks this increase in cellular hemoglobin concentration in human RBCs in a concentration-dependent fashion. Senicapoc (10 mg/kg, twice a day) induces a significant increase in hematocrit (Hct) after 11 days of dosing in the sickle cell disease (SAD) mouse^[3]. Senicapoc (30 mg/kg, p.o.) reduces airway hyperresponsiveness, eosinophil numbers in bronchoalveolar lavage taken 48 hours post-allergen challenge, and vascular remodelling in the sheep. Senicapoc-treated sheep also demonstrated reduced airway hyperresponsiveness, requiring a significantly higher dose of carbachol to increase resistance by 100% compared to allergen-challenged vehicle-control sheep^[4].