CAS:33342-05-1Gliquidone

Synonyms: Glurenorm

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

33342-05-1

储存条件

分子式

C27H33N3O6S

运输

蓝冰

分子量

527.63

别名

Glurenorm

溶解度

DMSO	200.0 mg/mL (379.1 mM)
Water	insoluble

动物实验配方

2% DMSO+corn oil

5 mg/mL

生物活性

描述Gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. Gliquidone reduced the body weight and the kidney weight/body weight ratio of mice. Gliquidone improved the kidney function, indicated by reductions in urinary protein, blood urea nitrogen, and serum creatinine and triglyceride. Gliquidone can ameliorate the diabetic symptoms of diabetic nephropathy through inhibiting Notch/Snail1 signaling pathway, improving anti-oxidative response and delaying renal interstitial fibrosis^[3]. Gliquidone treatment effectively reduced urinary protein in GK rats with diabetic nephropathy by improving glomerular lesions and promoting tubular reabsorption^[4]. Moreover, using gliquidone nanoparticles revealed ~2.5-fold increase in Cmax when taken orally in the form of hard gelatin capsules in comparison to free gliquidone. The developed strategy of gliquidone nanoparticles possess a keen potential for exhibiting anti-diabetic effect^[5].