CAS:304-20-1Hydralazine hydrochloride

Synonyms: Apresoline

Hydralazine HCl is a direct-acting vasodilator that is used as an antihypertensive agent.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

304-20-1

储存条件

分子式

C8H9ClN4

运输

蓝冰

分子量

196.64

别名

Apresoline

溶解度

DMSO	insoluble
Water	55.0 mg/mL (279.7 mM) warming

动物实验配方

0.5% CMC-Na

31 mg/mL

suspension

生物活性

描述Hydralazine hydrochloride (HHC) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. The preliminary IV administration of dihydralazine allowed a reduced volatile agent concentration which attenuated undesirable haemodynamic effects, in spite of renin and norepinephrine release, and permitted a rapid intraoperative awakening^[3]. Hydralazine hydrochloride may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs (randomized controlled trials)^[4]. The suitability of the prepared HHC sublingual tablets for use in rapid control on hypertensive crisis especially in pregnant women as an alternate to parenteral administration^[5]. The combination consists of 20 mg of isosorbide and 37.5 mg hydralazine hydrochloride in a fixed dose that functions as a nitric oxide enhancer and an antioxidant, and helps to prevent tolerance to the prolonged use of nitrate^[6].