CAS:28643-80-3Nigericin Sodium

Synonyms: Nigericin Sodium Salt

Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

技术信息

CAS号

28643-80-3

储存条件

分子式

C40H67NaO11

运输

蓝冰

分子量

746.94

别名

Nigericin Sodium Salt

溶解度

动物实验配方

生物活性

描述Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator. Nigericin (0.1 µM) inhibits proliferation, migration, invasion and clonogenicity of H460 lung cancer cells^[3]. A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM) and Fluo3 fluorescence (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM) and cytosolic pH (0.1-1 nM). Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance^[4]. Nigericin could selectively target CSCs (Cancer stem cells) and sensitize CSCs in NPC (Nasopharyngeal carcinoma) to the widely used clinical drug cisplatin both in vitro and in vivo^[5]. Nigericin exhibits great toxicity for the HT29 and SW116 cell line with IC50 of 12.92±0.25 μM and 15.86±0.18 μM. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions. HT29 cells treated with nigericin induced an increase in E-cadherin expression and a decrease in the vimentin expression relative to vehicle controls^[6].