CAS:1401242-74-7ML277

Synonyms: CID-53347902

ML277 is a potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

1401242-74-7

储存条件

分子式

C23H25N3O4S2

运输

蓝冰

分子量

471.59

别名

CID-53347902

溶解度

DMSO	320.0 mg/mL (678.6 mM)
Water	insoluble

动物实验配方

生物活性

描述ML277 was identified as a potent activator of KCNQ1 channels (EC50=260 nM). ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel^[3]. Modulations of human KCNQ1 channels by ML277 in Xenopus oocytes was tested. ML277 exclusively changes the pore opening properties of the AO (activated) state without altering the IO (intermediate) state, but does not affect VSD (voltage-sensing domain) activation. These observations support a distinctive mechanism responsible for the VSD-pore coupling at the AO state that is sensitive to ML277 modulation^[4].