CAS:4360-12-7Ajmaline

Synonyms: Cardiorythmine;(+)-Ajmaline;Gilurytmal

Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

4360-12-7

储存条件

分子式

C20H26N2O2

运输

蓝冰

分子量

326.43

别名

Cardiorythmine;(+)-Ajmaline;Gilurytmal

溶解度

DMSO	215.0 mg/mL (658.6 mM)
Water	insoluble

动物实验配方

生物活性

描述Ajmaline, a class 1a antiarrhythmic drug, accentuates the J wave in Brugada syndrome. Ajmaline significantly decreases the J-wave amplitude in ER (early repolarization) and prolongs the QRS width significantly less than in patients with Br (Brugada type 1 electrocardiogram)^[3]. Ajmaline challenge is commonly used for the diagnosis of Brugada syndrome. Slow and rapid infusions of ajmaline have identical diagnostic performances on suspected Brugada electrocardiograms. Owing to the risk of severe proarrhythmia, a slow infusion rate, allowing early discontinuation, should be recommended^[4].