CAS:353262-04-1NS-6180

NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

353262-04-1

储存条件

分子式

C16H12F3NOS

运输

蓝冰

分子量

323.33

别名

溶解度

DMSO	120.0 mg/mL (371.1 mM)
Water	insoluble

动物实验配方

生物活性

描述NS6180 is a novel potent and selective KCa3.1 channel inhibitor (IC50 = 9 nM) preventing T-cell activation and inflammation. NS6180 inhibited endogenously expressed K(Ca) 3.1 channels in human, mouse and rat erythrocytes, with similar potencies (15-20 nM). NS6180 suppressed rat and mouse splenocyte proliferation at submicrolar concentrations and potently inhibited IL-2 and IFN-γ production, while exerting smaller effects on IL-4 and TNF-α and no effect on IL-17 production. Despite poor plasma exposure, NS6180 (3 and 10 mg/kg b.i.d.) dampened colon inflammation and improved body weight gain as effectively as the standard IBD (inflammatory bowel disease) drug sulfasalazine (300 mg/kg q.d.)^[3].