CAS:10238-21-8Glibenclamide

Synonyms: Glyburide

Glibenclamide is a sulfonylurea compound that modulates insulin production.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

10238-21-8

储存条件

分子式

C23H28ClN3O5S

运输

蓝冰

分子量

494.00

别名

Glyburide

溶解度

动物实验配方

生物活性

描述Glibenclamide (Gli) is a selective inhibitor of ATP-sensitive K+ channel. Gli inhibited cell proliferation assessed by a clonogenic method in a dose dependent manner, with an increment in the population doubling time. When cell cycle analysis was performed by flow cytometry, Gli induced a significant cell-cycle arrest in G0/G1 phase, together with an up-regulation of p27 levels and a diminution in cyclin E expression, both evaluated by immunoblot^[3]. The GLUT1 expression was found to be affected by the glucose and insulin levels and can be modulated by glibenclamide in severely and mildly diabetic rats. Glibenclamide can prevent the liver damage caused by severe hyperglycemia^[4]. Glibenclamide caused more hypoglycemia than other secretagogues and other sulfonylureas. Glibenclamide was not associated with an increased risk of cardiovascular events, death, or weight gain^[5].