CAS:29094-61-9Glipizide

Synonyms: CP-28720;K 4024

Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

29094-61-9

储存条件

分子式

C21H27N5O4S

运输

蓝冰

分子量

445.54

别名

CP-28720;K 4024

溶解度

DMSO	180.0 mg/mL (404.0 mM) warming
Water	insoluble

动物实验配方

生物活性

描述Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Mechanism of action is produced by blocking potassium channels in the beta cells of the islets of Langerhans. By partially blocking the potassium channels, the cell remains depolarized, increasing the time the cell spends in the calcium release stage, which results in signaling leading to calcium influx. The increase in calcium will initiate more insulin release from each beta cell. Sulfonylureas may also cause the decrease of serum glucagon and potentiate the action of insulin at the extrapancreatic tissues^[3]. Glipizide treatment decreased dilated renal tubule number, improved glomerulus integrity, and reduced inflammatory infiltration. Glipizide blocks renal interstitial fibrosis by inhibiting AKT signaling pathway^[4]. Glipizide release from mucoadhesive microcapsules was slow and extended over longer periods of time and depended on composition of the coat. In the in vivo evaluation, alginate-Carbopol microcapsules could sustain the hypoglycemic effect of glipizide over a 14-hour period^[5].