CAS:1222781-70-5ML133 Hydrochloride

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ML133 HCl (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 Cat No. FB09767Cas No. 1222781-70-5

ML133 HCl selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1865 mL
- 15.9327 mL
- 31.8654 mL
- 5 mM
- 0.6373 mL
- 3.1865 mL
- 6.3731 mL
- 10 mM
- 0.3187 mL
- 1.5933 mL
- 3.1865 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1222781-70-5

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C19H20ClNO

运输

蓝冰

分子量

313.82

别名

溶解度

DMSO	63.0 mg/mL (200.8 mM)
Water	Insoluble
Ethanol	6.0 mg/mL (19.1 mM)

动物实验配方

靶点数据

生物活性

靶点 Potassium Channel Kir2.1

IC50:290nM(pH8.5)
描述ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of Kir2.x family channels. ML133 has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date^[3]. Transplantation of ML133-treated or Kir2.1 knockdown EPCs (Endothelial progenitor cells) facilitated re-endothelialization in the rat injured arterial segment and inhibited neointima formation in vivo. In parallel, ML133 significantly enhanced autophagy and autophagic flux. After suppression of autophagy by 3-methyladenine (3-MA), the effects of ML133 on in vitro function and in vivo endothelialization capacity of EPCs were significantly inhibited^[4].