CAS:53716-49-7Carprofen

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Carprofen reduces inflammation by inhibition of COX-2 with IC50 of 30 nM, does not interfere with COX-1 activity.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

53716-49-7

储存条件

分子式

C15H12ClNO2

运输

蓝冰

分子量

273.71

别名

溶解度

动物实验配方

生物活性

靶点 COX2

IC50:30nM
描述Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively^[3]. Carprofen (10 µg/mL) shows cytoprotective effects in CCL (cranial) and CaCL (caudal) cells and decreases apoptosis of both cells. Carprofen (10 μg/mL) had the greatest cytoprotective effects for CCL and CaCL cells^[4]. Carprofen acts in vivo on target tissues as COX-1-sparing drugs by sparing gastric PGE1 and PGE2 synthesis and production of TXB2 (thromboxane B2) by platelets^[5]. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR (minimum alveolar concentration for blunting adrenergic response) in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction^[6].