CAS:57-96-5(±)-Sulfinpyrazone

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(±)-Sulfinpyrazone 苯磺保泰松 Cat No. FB00053Cas No. 57-96-5

Synonyms: G-28315;NSC 75925

(±)-Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4723 mL
- 12.3615 mL
- 24.7230 mL
- 5 mM
- 0.4945 mL
- 2.4723 mL
- 4.9446 mL
- 10 mM
- 0.2472 mL
- 1.2362 mL
- 2.4723 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

57-96-5

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C23H20N2O3S

运输

蓝冰

分子量

404.48

别名

G-28315;NSC 75925

溶解度

DMSO	79.0 mg/mL (195.3 mM)
Water	Insoluble
Ethanol	63.0 mg/mL (155.8 mM)

动物实验配方

靶点数据

生物活性

描述(±)-Sulfinpyrazone is an orally active and potent uricosuric agent for chronic and intermittent gouty arthritis. Sulfinpyrazone has antithrombotic and platelet inhibitory effects. The normal total dose of sulfinpyrazone as an antithrombotic agent is 800 mg daily. The drug has been used continuously for up to 4 years with no serious adverse reactions or laboratory abnormalities. Sulfinpyrazone is not a substitute for conventional anticoagulant agents (e.g. the coumarin derivatives) in the treatment of venous thrombosis, but is an important drug for the treatment of conditions associated with arterial thrombosis and possibly for the prophylaxis of recurrent venous thrombosis^[3]. In rats with kaolin-induced paw oedema this compound is able to restore the markedly prolonged euglobulin clot lysis time in an oral dose of 30 mg/kg, whereas salicylate and dipyridamole are somewhat less active in this respect. Beside these effects, sulfinpyrazone protects rabbits from arachidonate-induced sudden death after a single oral dose of 10 - 30 mg/kg^[4].