CAS:80382-23-6Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate

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Loxoprofen Sodium 洛索洛芬钠 Cat No. FB13036Cas No. 80382-23-6

Loxoprofen Sodium is a non-selective cyclooxygenase inhibitor, a nonsteroidal anti-inflammatory drug (NSAID) working by reducing the synthesis of prostaglandins from arachidonic acid.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7274 mL
- 18.6372 mL
- 37.2745 mL
- 5 mM
- 0.7455 mL
- 3.7274 mL
- 7.4549 mL
- 10 mM
- 0.3727 mL
- 1.8637 mL
- 3.7274 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

80382-23-6

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C15H17NaO3

运输

蓝冰

分子量

268.28

别名

溶解度

DMSO	Insoluble
Water	51.0 mg/mL (190.1 mM)
Ethanol	Insoluble

动物实验配方

靶点数据

生物活性

描述Loxoprofen sodium, an anti-inflammatory prodrug (NSAID), is a nonselective COX inhibitor with IC50s of 6.5 μM and 13.5 μM for COX-1 and COX-2 in human whole blood assays, respectively^[1]. Both loxoprofen sodium and celecoxib were well tolerated for the relief of acute postoperative pain after spinal surgery. A single administration of loxoprofen showed superior and rapid effectiveness compared with celecoxib for both slight and severe postoperative pain^[2]. In a rat air pouch model, oral administration of loxoprofen sodium lowered prostaglandin (PG) E2 in both fluid exudates of the inflammatory pouch and stomach tissue with ED50 values of 2.0 and 2.1 mg/kg, respectively. Additionally, platelet thromboxane B2 production was also inhibited by loxoprofen sodium (ED50 of 0.34 mg/kg). In a rat carrageenan-induced paw edema model, loxoprofen sodium dose-dependently reduced the paw edema, accompanied by a decrease in PGE2 content in inflamed paw exudates^[3].