CAS:6024-85-7Tetrahydropalmatine HCl

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Synonyms: Gindarine HCl;1-Tetrahydropalmitine HCl

Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

6024-85-7

储存条件

分子式

C21H26ClNO4

运输

蓝冰

分子量

391.89

别名

Gindarine HCl;1-Tetrahydropalmitine HCl

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

生物活性

描述Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. It suppresses activation of the NF-kB signaling pathway, which results in regulation of IL-8 expression and specifically blocks the ERK1=2 and p38 MAPK signaling pathways. L-THP results in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP causes activation of caspase and resulted in apoptosis. l-THP possesses a blocking effect on dopamine D1 and D2 receptors and voltage-sensitive Ca2+ channels.