CAS:123663-49-0Iguratimod

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Iguratimod 艾拉莫德 Cat No. FB03449Cas No. 123663-49-0

Synonyms: T 614

Iguratimod is a selective inhibitor of COX2 (IC50 = 20 μM/7.7 μg/mL) and several inflammatory cytokines including interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor, it's an anti-inflammatory agent.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6712 mL
- 13.3558 mL
- 26.7117 mL
- 5 mM
- 0.5342 mL
- 2.6712 mL
- 5.3423 mL
- 10 mM
- 0.2671 mL
- 1.3356 mL
- 2.6712 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

123663-49-0

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C17H14N2O6S

运输

蓝冰

分子量

374.37

别名

T 614

溶解度

DMSO	48.0 mg/mL (128.2 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

靶点数据

生物活性

描述Iguratimod (T-614) is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod (0.1, 1, 10 μg/mL) inhibits bradykinin-stimulated PGE2 (prostaglandin E2) release from fibroblasts. Iguratimod suppresses the COX activity from bradykinin stimulated fibroblasts in a concentration-dependent manner, with an IC50 of 48 μg/mL. Iguratimod (10 and 30 μg/mL) also dose-dependently inhibits COX-2 mRNA levels^[3]. Mechanical paw withdrawal thresholds and the expression levels of pERK (phosphorylated extracellular signal-related kinase) and c-Fos declined in a dose-dependent manner in rats treated with iguratimod, and bone destruction severity was also reduced^[4]. In addition, Iguratimod potently inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM. Iguratimod is synergetic with glucocorticoids in vitro. Iguratimod (20 mg/kg i.p.) shows significantly increased survival in BALB/c mice that are vulnerable to endotoxemia, and attenuates TNFα release measured in serum isolated 90 min post-LPS administration in wild-type C57BL/6 mice^[5].