CAS:188817-13-2SC-560

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SC-560 5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑 Cat No. FB09207Cas No. 188817-13-2

SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8349 mL
- 14.1747 mL
- 28.3495 mL
- 5 mM
- 0.5670 mL
- 2.8349 mL
- 5.6699 mL
- 10 mM
- 0.2835 mL
- 1.4175 mL
- 2.8349 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

188817-13-2

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C17H12ClF3N2O

运输

蓝冰

分子量

352.74

别名

溶解度

DMSO	190.0 mg/mL (538.6 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

靶点 COX1

IC50:0.009μM COX2

IC50:6.3μM
描述The cyclooxygenase (COX) enzymes (COX-1 and COX-2) catalyze the bis-oxygenation of free arachidonic acid to prostaglandin (PG) H₂, the precursor of other PGs and thromboxane (Tx). SC-560 is a selective COX-1 inhibitor with an IC₅₀ value of 9 nM. It shows much less inhibitory potency against COX-2 with an IC₅₀ value of 6.3 μM. SC-560 decreased COX-1-dependent TxB₂ production in human platelets with an IC₅₀ value of 2.5 nM. It also reduced COX-2-dependent PGE₂ synthesis in LPS-stimulated human monocytes with an IC₅₀ value of 1.8 nM. Oral administration of SC-560 (10 or 30 mg/kg) one hour before the whole blood assay inhibited ionophore-stimulated TxB₂ production in rats. Oral dosing with SC-560 (0.1-100 mg/kg) blocked the production of TxB₂ in a concentration-dependent manner in rat inflamed skin. SC-560 at 100 mg/kg showed 40% inhibition on PGE₂ production in LPS-induced rat air pouch. It also efficiently inhibited PGE₂ synthesis in stomach mucosa with an ED₅₀ value of 0.2 mg/kg. However, 30 mg/kg SC-560 exhibited no significant effect on the onset of edema or hyperalgesia.

靶点	Description	IC50
COX1		IC50:0.009μM
COX2		IC50:6.3μM