CAS:22161-81-5(S)-Ketoprofen

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Synonyms: Dexketoprofen

(S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

22161-81-5

储存条件

分子式

C16H14O3

运输

蓝冰

分子量

254.28

别名

Dexketoprofen

溶解度

DMSO	500.0 mg/mL (1966.3 mM)
Water	insoluble

动物实验配方

生物活性

描述(S)-Ketoprofen is a nonsteroidal anti-inflammatory and analgesic agent that nonselectively inhibits cyclooxygenase, with both COX-1 and COX-2 inhibition^[3]. Intrathecal (S)-(+)-Ketoprofen caused dose-dependent neurohistopathological changes in rats on days 3 and 7 after injection, suggesting that (S)-(+)-Ketoprofen should not be intrathecally administered^[4]. Following PO administration, S-(+)-ketoprofen achieved maximum plasma concentrations of 4.91 ± 0.76 and 12.47 ± 0.62 μg/ml at two dose levels (1 mg/kg and 3 mg/kg), respectively. The absolute bioavailability after PO route was 88.66 ± 12.95% and 85.36 ± 13.90%, respectively^[5]. The spinal injection of (S)-ketoprofen alone or of morphine alone did not produce antiallodynic activity. (S)-ketorolac combined with morphine also produced antiallodynia. (S)-ketoprofen, but not (R)-ketoprofen, blocked the second phase of the formalin-induced flinch response; Again, (S)-, but not (R)-ketoprofen, interacted synergistically with spinal morphine in suppressing the phase II formalin response^[6].