CAS:1011244-68-0TFAP

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TFAP TFAP Cat No. FB12135Cas No. 1011244-68-0

Synonyms: COX-1 Inhibitor IV

TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor (IC50 = 0.80 and 210 µM against ovine COX-1 and COX-2, respectively).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5558 mL
- 17.7788 mL
- 35.5577 mL
- 5 mM
- 0.7112 mL
- 3.5558 mL
- 7.1115 mL
- 10 mM
- 0.3556 mL
- 1.7779 mL
- 3.5558 mL
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技术信息

CAS号

1011244-68-0

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C13H10F3N3O

运输

蓝冰

分子量

281.23

别名

COX-1 Inhibitor IV

溶解度

DMSO	200.0 mg/mL (711.2 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Biosynthesis of prostaglandins from arachidonic acid (AA) is catalyzed by cyclooxygenase (COX), which exists as COX-1 and COX-2. AA is in turn released from the cell membrane upon neopathological stimuli. COX inhibitors interfere in this catalytic and disease onset process^[1]. TFAP is a selective COX-1 inhibitor with an IC₅₀ value of 0.8 μM. Although TFAP shows potent analgesic effect without gastric damage, the urine after administration of TFAP becomes red-purple^[2].