CAS:91714-93-1Bromfenac Sodium

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Bromfenac Sodium 溴芬酸钠 Cat No. FB04197Cas No. 91714-93-1

Synonyms: AHR 10282R

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8078 mL
- 14.0392 mL
- 28.0783 mL
- 5 mM
- 0.5616 mL
- 2.8078 mL
- 5.6157 mL
- 10 mM
- 0.2808 mL
- 1.4039 mL
- 2.8078 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

91714-93-1

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C15H11BrNNaO3

运输

蓝冰

分子量

356.15

别名

AHR 10282R

溶解度

DMSO	70.0 mg/mL (196.5 mM)
Water	69.0 mg/mL (193.7 mM)
Ethanol	2.0 mg/mL (5.6 mM)

动物实验配方

靶点数据

生物活性

描述Bromfenac Sodium is a brominated NSAID (nonsteroidal anti-inflammatory drugs) with strong in vitro anti-inflammatory potency. In rat models of acute (carrageenan paw edema) and chronic (adjuvant arthritis) inflammation, preparations of bromfenac at concentrations as low as 0.01-0.32% (0.01-0.32 mg bromfenac) produced significant anti-inflammatory activity when applied to the injected paw or to the backs of rats, and the same dose showed topical analgesic activity in the acetylcholine-induced abdominal constriction test in mice^[3]. Bromfenac protects against TGF-β1-induced synthesis of fibronectin, α-SMA, and collagen III in human pterygium fibroblasts and primary human conjunctival fibroblasts at least in part by inactivating the AKT and ERK pathways^[4]. Bromfenac was well tolerated when given alone or in combination with intravitreal anti-vascular endothelial growth factor agents, topical corticosteroids, or topical mast-cell stabilizers. The most common adverse event reported was ocular irritation^[5].