CAS:341-88-82-Heptyl-4-hydroxyquinolin-1-ium-1-olate

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HQNO 2-庚基-4-羟基喹啉 1-氧化物 Cat No. FB17210Cas No. 341-88-8

HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.

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18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8559 mL
- 19.2795 mL
- 38.5589 mL
- 5 mM
- 0.7712 mL
- 3.8559 mL
- 7.7118 mL
- 10 mM
- 0.3856 mL
- 1.9279 mL
- 3.8559 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	341-88-8	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C16H21NO2	运输	蓝冰
分子量	259.34	别名

靶点数据

生物活性

描述Type II NADH: quinone oxidoreductase (NDH-2) is a membrane-bound bi-substrate enzyme that catalyses the cytoplasmic oxidation of NADH and reduction of quinone in the membrane. HQNO is a potent mitochondrial NDH-2 inhibitor in many species. Wide type NDH-2 had an IC₅₀ value of 10.5 ± 1.3 μM HQNO in the presence of 400 μM menadione (MD). In the presence of 50 μM MD, the IC₅₀ value for HQNO decreased slightly to 7.3 ± 1.2 μM and near complete inhibition was observed with > 50 μM HQNO^[1].
作用机制HQNO is nested into the slot-shaped tunnel of the Q-site, in which the quinone-head group is clamped by Q317 and I379 residues, and hydrogen-bonds to FAD^[1].