CAS:541-46-8Isovaleramide

Synonyms: 3-Methylbutanamide

Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

541-46-8

储存条件

分子式

C5H11NO

运输

蓝冰

分子量

101.15

别名

3-Methylbutanamide

溶解度

DMSO	225.0 mg/mL (2224.5 mM)
Water	200.0 mg/mL (1977.3 mM) warming

动物实验配方

生物活性

描述Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant. Isovaleramide at 100 mg/kg, p.o, evidenced a 90% index protection against the maximal electroshock seizure in mice (MES), comparable to the reference agent: sodium phenytoin (20 mg/kg, p.o, 100%). In the in vitro assay, isovaleramide (300 µM) exhibited a 42% of inhibition of the binding of ³H-FNZ to its sites^[3]. Isovaleramide, was essentially uncompetitive inhibitors of purified horse and rat liver alcohol dehydrogenases with respect to ethanol as substrate. The uncompetitive inhibition constants for isovaleramide for rat liver alcohol dehydrogenase was 20 mM, in vitro, whereas in vivo the values was 180 mumol/kg^[4].