CAS:2156-56-1Sodium 2,2-dichloroacetate

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Sodium 2,2-dichloroacetate 二氯乙酸钠 Cat No. FB09385Cas No. 2156-56-1

Synonyms: DCA

Sodium 2,2-dichloroacetate is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 183 and 80 μM for PDK2 and PDK4 respectively, with tumor growth inhibition properties.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.6260 mL
- 33.1301 mL
- 66.2603 mL
- 5 mM
- 1.3252 mL
- 6.6260 mL
- 13.2521 mL
- 10 mM
- 0.6626 mL
- 3.3130 mL
- 6.6260 mL
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技术信息

CAS号

2156-56-1

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C2HCl2NaO2

运输

蓝冰

分子量

150.92

别名

DCA

溶解度

DMSO	28.0 mg/mL (185.5 mM)
Water	28.0 mg/mL (185.5 mM)
Ethanol	29.0 mg/mL (192.2 mM)

动物实验配方

靶点数据

生物活性

描述DCA can trigger apoptosis of human lung, breast and brain cancer cells. After DCA treatment, cancer cells shows increased levels of ROS, depolarization of the MMP in vitro and increased apoptosis both in vitro and in vivo. DCA inhibits the activity of pyruvate dehydrogenase kinase (PDK), thereby stimulating the mitochondrial enzyme pyruvate dehydrogenase (PDH). When turned off, PDH no longer converts pyruvate to acetyl-CoA required for mitochondrial respiration and glucose dependent oxidative phosphorylation. DCA thus shifts cellular metabolism from glycolysis to glucose oxidation, decreasing the mitochondrial membrane potential gradient and helping to open mitochondrial transition pores. This metabolic switch facilitates translocation of pro-apoptotic mediators like cytochrome c (cyt c) and apoptosis inducing factor (AIF), both of which stimulate apoptosis. DCA thereby drives cancer cells to commit suicide by apoptosis.