CAS:2029049-79-2ML390

ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

技术信息

CAS号

2029049-79-2

储存条件

分子式

C21H21F3N2O3

运输

蓝冰

分子量

406.40

别名

溶解度

DMSO	127.5 mg/mL (313.7 mM)
Water	insoluble

动物实验配方

生物活性

描述Dihydroorotate dehydrogenase (DHODH) catalyzes the oxidation of dihydroorotate to orotate in de novo pyrimidine synthesis, e.g., uridine 5′-monophosphate. ML390 is a small-molecule probe active in overcoming differentiation arrest in a model of AML (acute myeloid leukemia). Its effect is due to inhibition of DHODH-catalyzed pyrimidine synthesis^[3]. ML390 is very well-tolerated with limited cytotoxicity at high concentration when assayed against cultures of normal human primary bone marrow cells. ML390 triggers myeloid differentiation in murine and human cell line models of acute myeloid leukemia. The stability of probe ML390 in PBS (0.1% DMSO) was measured and the probe is stable as approximately 100% was present after 24 hours of incubation^[4].
作用机制The (R)-amino tetralin group of ML390 is located within the innermost part of the cavity and makes the closest contact^[3].