CAS:1405-86-3Glycyrrhizic acid

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Glycyrrhizic Acid 甘草酸 Cat No. FB05956Cas No. 1405-86-3

Synonyms: Glycyrrhizin

Glycyrrhizic Acid is a naturally occuring non-selective and competitive 11β-hydroxysteroid dehydrogenase inhibitor with protective effect against glucocorticoid-induced osteoporosis. It also inhibited HMGB1.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2152 mL
- 6.0758 mL
- 12.1517 mL
- 5 mM
- 0.2430 mL
- 1.2152 mL
- 2.4303 mL
- 10 mM
- 0.1215 mL
- 0.6076 mL
- 1.2152 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1405-86-3

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C42H62O16

运输

蓝冰

分子量

822.93

别名

Glycyrrhizin

溶解度

DMSO	98.0 mg/mL (119.1 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (121.5 mM)

动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water

10 mg/mL

靶点数据

生物活性

描述Monoamine oxidases (MAO) are a group of enzymes that inactivate monoamine neurotransmitters and catalyze the oxidation of monoamines ingested in food. Glycyrrhizic acid (GA) is a MAO inhibitor with an IC₅₀ value of 0.16 μM. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that can be released in response to necrotic or inflammatory signals. GA is also an inhibitor of HMGB1. In HBV transgenic mouse, GA administration (10 mg/mouse) ameliorated the severity of cytotoxic T lymphocytes‐induced liver disease. GA also competitively inhibits the enzymatic activity of 11-hydroxysteroid dehydrogenase type 2 (11-HSD2). By treating rats with 60 and 120 mg/kg GA (twice a day) for 2 weeks, the level of NAD⁺-dependent 11-HSD2 activity in kidney was significantly decreased to 44% and 34%, respectively, as compared to control group. A significant reduction in renal 11-HSD2 protein and mRNA expressions was also observed in rats dosed with 120 mg/kg GA when compared to vehicle-treated group.
动物研究
剂量
Rat: 15 mg/kg^[3] (p.o.), 30 mg/kg - 120 mg/kg^[2] (p.o.)

给药途径
p.o.

动物研究
剂量	Rat: 15 mg/kg^[3] (p.o.), 30 mg/kg - 120 mg/kg^[2] (p.o.)
给药途径	p.o.