CAS:554-92-7Trimethobenzamide HCl

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Synonyms: Ro 2-9578

Trimethobenzamide HCl is a dopamine D2 receptor antagonist and antiemetic drug.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

554-92-7

储存条件

分子式

C21H29ClN2O5

运输

蓝冰

分子量

424.92

别名

Ro 2-9578

溶解度

DMSO	195.0 mg/mL (458.9 mM)
Water	175.0 mg/mL (411.8 mM)

动物实验配方

生物活性

描述Trimethobenzamide HCl is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center^[1]. Trimethobenzamide was shown to be significantly better than placebo in relieving periodic and total nausea over the 48-hour study. Vomiting incidence was also reduced in the group receiving trimethobenzamide^[2]. Trimethobenzamide HCl was found to have more toxic and teratogenic potential on embryonic growth and development in cultured rat embryos^[3]. Open-label studies suggest that the combination of trimethobenzamide and diphenhydramine (TMB/DPH) may provide effective relief in a high proportion of migraineurs^[4]. In utero TMB (Trimethobenzamide) exposure may cause growth retardation, neurological damage in the developing brain and intestine, and hepatic damage^[5].