CAS:10563-70-9Melitracen hydrochloride

Synonyms: Thymeol hydrochloride; N7001

Melitracen HCl, a member of anthracenes, is an antagonist of dopamine D1 and D2 receptors. It is used as an antidepressant.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

10563-70-9

储存条件

分子式

C21H26ClN

运输

蓝冰

分子量

327.89

别名

Thymeol hydrochloride; N7001

溶解度

DMSO	65 mg/ml (198.24 mM)
Water	65 mg/ml (198.24 mM)

动物实验配方

生物活性

描述Melitracen HCl is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space. Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals^[1]. The efficacy of flupentixol-melitracen in the adjuvant therapy of ulcerative colitis is better than traditional drug treatments^[2]. Flupentixol and melitracen combined with specific immunotherapy could sifnificantlly relieve clinical symptom, quality of life and mental depression.is a safe and reliable therapeutic regimen for further improving clinical symptoms,quality of life,mental statusand the clinical efficacy in moderate to severe persistent with anxiety anddepression^[3].