CAS:84225-95-6(S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide

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Raclopride (S)-3,5-二氯-N-((-乙基吡咯烷-2-基)甲基)-2-羟基-6-甲氧基苯甲酰胺 Cat No. FB16390Cas No. 84225-95-6

Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively .

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8799 mL
- 14.3994 mL
- 28.7988 mL
- 5 mM
- 0.5760 mL
- 2.8799 mL
- 5.7598 mL
- 10 mM
- 0.2880 mL
- 1.4399 mL
- 2.8799 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	84225-95-6	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C15H20Cl2N2O3	运输	蓝冰
分子量	347.24	别名

靶点数据

生物活性

描述Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively^[1]. It is one of the most frequently used in vivo D2 tracers (at low doses) for assessing drug-induced receptor occupancy (RO) in animals and humans. It is also commonly used as a pharmacological blocker (at high doses) to occupy the available D2 receptors and antagonize the action of dopamine or drugs on D2 in preclinical studies. The PK-RO (pharmacokinetic-receptor occupancy) model could facilitate the selection of optimal dose and dosing time when raclopride is used as tracer or as pharmacological blocker in various rat studies^[2]. Microinjection of Raclopride into the mPOA (medial preoptic area) has been shown to promote nursing postures in lactating dams with no effects on active maternal behavior^[3].