CAS:925432-73-13,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide

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SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

925432-73-1

储存条件

分子式

C26H29N5O4S

运输

蓝冰

分子量

507.60

别名

溶解度

动物实验配方

生物活性

描述Sirtuin-1 (SIRT1), a NAD⁺-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. SRT1460 is a potent SIRT1 activator with an EC_1.5 (concentration required to increase enzyme activity by 50%) value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues^[1]. Treatment with different concentrations of SRT1460 inhibited cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. SRT1460 was also shown to inhibited cell growth by the Trypan blue exclusion and in the anchorage-independent cell growth assays in Patu8988t^[2].
作用机制SRT1460 binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain^[1].