CAS:304896-28-4AGK2

您的位置 : 首页 / Epigenetics / Sirtuin / AGK2

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

304896-28-4

储存条件

分子式

C23H13Cl2N3O2

运输

蓝冰

分子量

434.27

别名

溶解度

DMSO	15.0 mg/mL (34.5 mM) warming
Water	insoluble

动物实验配方

8% DMSO+30% PEG 300+water

1.4 mg/mL

生物活性

描述AGK2 is a selective Sirt2 inhibitor with IC50 value of 3.5 μM (measured by SIRT2 enzymatic assay) with almost no activity against SIRT1 and SIRT3 up to 40μM. AGK2 is usually used in research of neuroprotection. Inhibition of Sirt2 by AGK2 at concentration of 10μM reducedα-Syn–mediated toxicity in cells. Administration of AGK2 at concentration of 500μM or 1000μM rescued α-Syn–mediated toxicity of dorsomedial dopamine neurons in a Drosophila PD model. Increased level of acetylated tubulin could be observed after treatment with AGK2. Treatment with AGK2 at concentration of 10μM for 6h could exacerbate H2O2 (0.5 or 1mM)-induced decreases in the intracellular ATP level in PC12 cells. Addition of 10μM AGK2 moderately increased the percentage of high-ploidy megakaryocytic cells.
动物研究
剂量
Mice: 15 mg/kg^[3] (i.v.); 10 mg/kg^[4] (i.p.), 82 mg/kg^[5] (i.p.)

给药途径
i.v., i.p.