CAS:119139-23-03,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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Synonyms: Ro 31-6233

Bisindolylmaleimide IV is an inhibitor of protein kinase C.

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18817579266

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描述The enzyme family protein kinase C (PKC) occupies a central role in the transduction of signals from a variety of mediators across the cell membrane. Inhibition of PKC may provide therapy for diseases such as rheumatoid arthritis (through inhibition of T-cell proliferation), cancer and AIDS (through inhibition of viral entry and viral gene expression). Bisindolylmaleimide IV is a potent PKC inhibitor, with IC₅₀s ranging from 0.1 to 0.55 μM. It also inhibits PKA (cAMP-dependent protein kinase) with IC₅₀s ranging from 3.1 to 11.8 μM^[1]. Moreover, Bisindolylmaleimide IV has a good anti-HCMV (human cytomegaloviru) activity with an IC₅₀ value of 0.2 μM^[2].