CAS:169939-93-9LY333531 Hydrochloride

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LY333531 HCl LY333531 盐酸盐 Cat No. FB00623Cas No. 169939-93-9

Synonyms: Ruboxistaurin;Ruboxistaurin HCl

LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively.

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9802 mL
- 9.9008 mL
- 19.8016 mL
- 5 mM
- 0.3960 mL
- 1.9802 mL
- 3.9603 mL
- 10 mM
- 0.1980 mL
- 0.9901 mL
- 1.9802 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

169939-93-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C28H29ClN4O3

运输

蓝冰

分子量

505.01

别名

Ruboxistaurin;Ruboxistaurin HCl

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

靶点数据

生物活性

描述LY333531 is a selective PKCβinhibitor with IC50 values of 4.7nM and 5.9nM for PKCβI and PKCβII isozyme, respectively, 76- and 61-fold selective for inhibition of PKCβI and PKCβII in comparison to PKCα(IC50=360nM). Oral administration of 1mg/kg LY333531 for a duration of 4 weeks prevented excessive PKCβ2 activation induced by hyperglycemia and attenuated cardiac diastolic dysfunction in rats with streptozotocin-induced diabetes. Also it suppressed the decreased expression of myocardial NO, Cav-3, phosphorylated p-Akt, and p-eNOS and also mitigated the augmentation of O₂^-, nitrotyrosine, Cav-1, and iNOS expression).
作用机制LY333531 is an ATP-competitive inhibitor.^[1]
动物研究
剂量
Pig: 0.5 mg/kg^[4] (p.o., twice daily) Rat: 1 mg/kg^[1] (p.o.); 0.1 mg/kg - 10 mg/kg^[5] (i.p.)

给药途径
p.o., i.p.

动物研究
剂量	Pig: 0.5 mg/kg^[4] (p.o., twice daily) Rat: 1 mg/kg^[1] (p.o.); 0.1 mg/kg - 10 mg/kg^[5] (i.p.)
给药途径	p.o., i.p.