PI3K
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01895 | ZSTK474 | 475110-96-4 | ZSTK474 inhibits class I PI3K isoforms with IC50s of of 16/44/4.6 and 49 nM for PΙ3Κα/β/δ and γ respectively. |
| FB01848 | XL147 Analogue | 956958-53-5 | XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. |
| FB02038 | TGX-221 | 663619-89-4 | TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, and is 1000-fold selective for p110β than p110α. |
| FB01379 | PI-103 | 371935-74-9 | PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. |
| FB02481 | PF-04979064 | 1220699-06-8 | PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC50 of 9.1 nM. |
| FB06540 | Myricetin | 529-44-2 | Myricetin, a natural flavonoid isolated and purified from the root bark of Myrica cerifera L. with antioxidant and anti tumor properties, is an inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM. |
| FB03751 | LY294002 | 154447-36-6 | LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays. |
| FB00921 | Wortmannin | 19545-26-7 | KY 12420 is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. |
| FB08083 | GSK2126458 | 1086062-66-9 | GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
| FB05366 | GDC-0941 | 957054-30-7 | GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β(11-fold) and p110γ(25-fold). |
| FB01374 | BEZ235 | 915019-65-7 | BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. |
| FB03810 | AZD6482 | 1173900-33-8 | AZD6482 is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ. |