CAS:1276121-88-0PF-3644022

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PF-3644022 Cat No. FB08625Cas No. 1276121-88-0

PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6705 mL
- 13.3526 mL
- 26.7052 mL
- 5 mM
- 0.5341 mL
- 2.6705 mL
- 5.3410 mL
- 10 mM
- 0.2671 mL
- 1.3353 mL
- 2.6705 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	1276121-88-0	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C21H18N4OS	运输	蓝冰
分子量	374.46	别名

靶点数据

生物活性

描述PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models.