CAS:625115-55-1Riociguat

Synonyms: BAY 63-2521

Riociguat acts as stimulator of soluble guanylate cyclase (sGC) that is used to treat ipulmonary hypertension.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

625115-55-1

储存条件

分子式

C20H19FN8O2

运输

蓝冰

分子量

422.42

别名

BAY 63-2521

溶解度

动物实验配方

生物活性

描述Riociguat is a potent sGC (soluble guanylate cyclase) stimulator with improved DMPK profile, used for the treatment of pulmonary hypertension. It directly stimulates sGC and sensitises it to its physiological stimulator, nitric oxide. It achieved threefold stimulation of cGMP formation in a recombinant sGC-overexpressing cell line with minimal effective concentration of 30nM. Oral administration of BAY 63-2521 at 10 mg/kg/day partially reversed the pulmonary arterial hypertension induced by monocrotaline in rats or in chronic treatment of hypoxic mice. The reversion of the right heart hypertrophy and the structural remodelling of the lung vasculature could also be observed.
动物研究
剂量
Rat； 0.1 mg/kg^[3] (i.v.); 10 mg/kg^[4] (p.o.) Mice: 30 mg/kg^[5] (p.o.)

给药途径
i.v., p.o.

动物药代数据
Animal Rats^[6]
F 35% - 65%
CL 1.3 L/kg·h
Vd_ss 1.2 L/kg