CAS:256376-24-6BAY 41-2272

BAY 41-2272 is an activator of guanylate cyclases (sGC).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

256376-24-6

储存条件

分子式

C20H17FN6

运输

蓝冰

分子量

360.39

别名

溶解度

DMSO	25.0 mg/mL (69.4 mM)
Water	insoluble

动物实验配方

生物活性

描述BAY 41-2272 is a potent sGC stimulator. BAY 41-2272 activates sGC by an NO-independent, but haem-dependent mechanism. BAY 41-2272 stimulated recombinant sGC at concentration ranging in 0.1nM to 100μM, which could not be blocked by high concentrations (65μM) of the NO scavengers PTIO. BAY 41-2272 at concentrations as low as 10–100 nM could stimulate sGC to a level that would be expected to cause biologically important increases in cGMP. Combination with NO could potentiate the BAY 41-2272 on the reaction. BAY 41-2272 exhibited anti-aggregatory as tail-bleeding time was prolonged in rats dosed of 0.3-3mg/kg BAY 41-2272 orally. Oral administration of BAY 41-2272 at dose of 1-10mg/kg to hypertensive rats induced a dose-dependent and long-lasting decrease in mean arterial blood pressure.
作用机制BAY 41-2272 binds to α1-subunit of sGC through Cys 238 and Cys 243.^[1]
动物研究
剂量
Rabbit: 0.1 mg/kg - 1 mg/kg^[2] (i.v.); 1 mg/kg - 10 mg/kg^[2] (p.o.) Mice: 0.3 mg/kg - 10 mg/kg^[3] (i.p.) Rat: 10 mg/kg^[4] (p.o.)

给药途径
i.v., p.o., i.p., p.o.

动物研究
剂量	Rabbit: 0.1 mg/kg - 1 mg/kg^[2] (i.v.); 1 mg/kg - 10 mg/kg^[2] (p.o.) Mice: 0.3 mg/kg - 10 mg/kg^[3] (i.p.) Rat: 10 mg/kg^[4] (p.o.)
给药途径	i.v., p.o., i.p., p.o.