DNA/RNA Synthesis
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01023 | YK-4-279 | 1037184-44-3 | YK 4-279 is a potent inhibitor of RNA Helicase A (RHA) that binding to the oncogenic transciption factor EWS-FLI1. |
| FB03417 | Vidarabine | 5536-17-4 | Vidarabine is an antiviral drug effects by interfering with the synthesis of viral DNA, which is used in treatment of herpes simplex and varicella zoster viruses. |
| FB08609 | Tosufloxacin Tosylate | 115964-29-9 | Tosufloxacin tosylate is an antibacterial agent that inhibits bacterial DNA gyrase inhibitor. |
| FB04219 | Thiolutin | 87-11-6 | Thiolutin is an antibiotic which inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Thiolutin also suppresses tumor cell-induced angiogenesis. |
| FB10989 | Thailanstatin A | 1426953-21-0 | Thailanstatin A is a spliceosome inhibitor that disrupts cancer by inhibiting DNA-editing machinery. |
| FB03955 | TH287 HCl | 1638211-05-8 | TH287 HCl is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. |
| FB08074 | SCR7 Pyrazine | 14892-97-8 | SCR7 pyrazine is a specific DNA ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ). |
| FB10233 | Saccharin 1-methylimidazole | 482333-74-4 | Saccharin 1-methylimidazole is a DNA/RNA synthesis activator. |
| FB10382 | RK-33 | 1070773-09-9 | RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. |
| FB04607 | Rifampicin | 13292-46-1 | Rifampicin is a bacterial RNA polymerase inhibitor used in the treatment of bacterial infections. |
| FB02894 | Rbin-1 | 328023-11-6 | Rbin-1 inhibits ATPase with GI50 of 136±7 nM, it is a potent, reversible, and specific chemical inhibitor of eukaryotic ribosome biogenesis. |
| FB10784 | Pyridostatin Trifluoroacetate | 1472611-44-1 | Pyridostatin Trifluoroacetate stabilizes and binds G-quadruplexe with Kd of 490 nM (cell-free assay), which targets the proto-oncogene c-kit, K-ras and Bcl-2. |
| FB03348 | Nelarabine | 121032-29-9 | Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
| FB10753 | Mupirocin | 12650-69-0 | Mupirocin is an antibiotic of the monoxycarbolic acid class and an isoleucyl t-RNA synthetase inhibitor that effective against Gram-positive bacteria, including MRSA. |
| FB03205 | ML216 | 1430213-30-1 | ML216 is a potent inhibitor of the DNA unwinding activity of BLM helicase, showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively. |
| FB10853 | LSS-11 | 1392014-36-6 | LSS-11 bound to DNA in vitro and in cell mainly by minor groove binding and significantly increased the stability of DNA, which could be fundamental for the biological activities of LSS-11. It can inhibit multiple DNA-associated processes and tumor growth. |
| FB03300 | LMI070 | 1562338-42-4 | LMI070 is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
| FB04894 | L67 | 325970-71-6 | L67 is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM. |
| FB08075 | L189 | 64232-83-3 | L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM. |
| FB03827 | Hydroxyurea | 127-07-1 | Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. |
| FB00191 | Gemcitabine HCl | 122111-03-9 | Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| FB01806 | Fludarabine Phosphate | 75607-67-9 | Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. |
| FB03108 | Floxuridine | 50-91-9 | Floxuridine is an oncology drug that belongs to antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. |
| FB00443 | Fidaxomicin | 873857-62-6 | Fidaxomicin is a macrocyclic antibiotic drug that inhibits RNA polymerase sigma subunit, and shows selective eradication of pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora. |
| FB11250 | FEN1 Inhibitor C3 | 2109805-87-8 | FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| FB11249 | FEN1 Inhibitor C2 | 1995893-58-7 | FEN1 inhibitor C2 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| FB11248 | FEN1 Inhibitor C1 | 824983-91-7 | FEN1 inhibitor C1 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| FB09948 | E-3330 | 136164-66-4 | E3330 is a potent and selective APE1 (Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
| FB11119 | DFP-11207 | 1296177-16-6 | DFP-11207 is a n orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. |
| FB09887 | Cytarabine | 147-94-4 | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. |
| FB00945 | CX-5461 | 1138549-36-6 | CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM. |
| FB09841 | CRT0044876 | 6960-45-8 | CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM. |
| FB10056 | COH29 | 1190932-38-7 | COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with IC50 value of 8 μM in KB cell. |
| FB03448 | Clofarabine | 123318-82-1 | Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
| FB10257 | Chebulinic Acid | 18942-26-2 | Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. |
| FB10236 | CeMMEC13 | 1790895-25-8 | CeMMEC13 inhibits the second bromodomain of TAF1 selectively with IC50 of 2.1 µM. |
| FB10235 | CeMMEC1 HCl | 2095432-53-2 | CeMMEC1 HCl is an N-methylisoquinolinone derivative that inhibits the second bromodomain of TAF1 (IC50=0.9 μM). |
| FB07245 | Capecitabine | 154361-50-9 | Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU, and used as an anti-cancer prodrug. |
| FB11236 | Brr2 Inhibitor C9 | 2104030-82-0 | Brr2 inhibitor C9 is an allosteric inhibitor targeting the spliceosomal RNA helicase Brr2, which implicated in autosomal-dominant retinitis pigmentosa, a group of progressive retinal degenerative disorders. |
| FB04898 | BRD7116 | 329059-55-4 | BRD7116 competitively binds to bacterial DNA gyrase, exhibits an EC50 of 200 nM for LSCe cells, with cell-non-autonomous anti-leukemia activity. |
| FB01592 | BMH-21 | 896705-16-1 | BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and does not cause phosphorylation of H2AX. |
| FB05535 | Beaucage Reagent | 66304-01-6 | Beaucage Reagent is potent in causing DNA cleavage. |
| FB04809 | BCX 4430 HCl | 222631-44-9 | BCX 4430 HCl is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrats broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. |
| FB01771 | BCX 4430 Free Base | 249503-25-1 | BCX 4430 free base is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and demonstrates broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. |
| FB04913 | BAY 57-1293 | 348086-71-5 | BAY 57-1293 represents a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex. |
| FB10806 | APE1 Inhibitor C10 | 1227098-30-7 | APE1 inhibitor C10 is a small molecular inhibitor which has a potent in treating Kaposi's sarcoma-associated herpesvirus (KSHV). |
| FB08386 | Ancitabine HCl | 10212-25-6 | Ancitabine HCl is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. |
| FB09865 | Adenine Sulfate | 321-30-2 | Adenine Sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with varieties of biochemistry roles. |
| FB10047 | Acelarin | 840506-29-8 | Acelarin is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
| FB07893 | 5-Fluorouracil | 51-21-8 | 5-Fluorouracil is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |