CAS:122111-03-9Gemcitabine hydrochloride

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Synonyms: LY 188011 HCl

Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

122111-03-9

储存条件

分子式

C9H12ClF2N3O4

运输

蓝冰

分子量

299.66

别名

LY 188011 HCl

溶解度

DMSO	50.0 mg/mL (166.9 mM) warming
Water	100.0 mg/mL (333.7 mM) warming

动物实验配方

0.5% CMC-Na

32 mg/mL

suspension

生物活性

描述Gemcitabine hydrochloride is the hydrochloride form of Gemcitabine. Gemcitabine (dFdCTP, LY-188011, NSC 613327, (+)-2'-Deoxy-2',2'-difluorocytidine) is a deoxycytidine analogue that has a spectrum of activity against solid tumors^[1]. Gemcitabine can inhibit DNA synthesis through a combination of two actions. The first, gemcitabine can inhibit ribonucleotide reductase (RR) and then cause the decrease of the deoxynucleotide pool sizes for DNA repair and synthesis^[2]^[3]. The second, gemcitabine inhibit DNA synthesis through competition with dCTP and incorporation into DNA^[4]^[4]. Gemcitabine can induce S-phase arrest and cell growth inhibition^[6].
作用机制Gemcitabine, as nucleoside analogue, can inhibit DNA synthesis through inhibition of ribonucleotide reductase and incorporation into DNA.^[2]^[3]

动物研究

剂量

Mice: 0.15 mg/kg - 300 mg/kg^[7] (i.v.) Dog: 3 mg/kg - 30 mg/kg^[8] (i.v.) LD50 = 500 mg/kg (orally in Mice and rats)^[9]

给药途径

i.v., p.o.

动物药代数据