CAS:55142-85-3Ticlopidine

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Ticlopidine is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.

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18817579266

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18817579266

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描述Ticlopidine is a selective and the first FDA-approved P2Y12 antagonist which can affect platelet aggregation when. It can be metabolized through cytochrome P450 in the liver and forms the active thienopyridine metabolites. The thienopyridine metabolites can irreversibly antagonize the P2Y12 receptor. This results in inhibition of the binding of the P2Y12 agonist 2-methylthio-ADP and the ADP-induced downregulation of adenylyl cyclase.
动物研究
剂量
Rat: 4 mg/kg, 10 mg/kg^[3] (p.o.), 10 mg/kg - 300 mg/kg^[4] (p.o.); 125 mg/kg^[5] (i.p.); 25 mg/kg^[6] (i.v.)

给药途径
p.o., i.p., i.v.

动物研究
剂量	Rat: 4 mg/kg, 10 mg/kg^[3] (p.o.), 10 mg/kg - 300 mg/kg^[4] (p.o.); 125 mg/kg^[5] (i.p.); 25 mg/kg^[6] (i.v.)
给药途径	p.o., i.p., i.v.